Variation in pelvic morphology may prevent the identification of anterior pelvic tilt

Pelvic tilt is often quantified using the angle between the horizontal and a line connecting the anterior superior iliac spine (ASIS) and the posterior superior iliac spine (PSIS). Although this angle is determined by the balance of muscular and ligamentous forces acting between the pelvis and adjacent segments, it could also be influenced by variations in pelvic morphology. The primary objective of this anatomical study was to establish how such variation may affect the ASIS-PSIS measure of pelvic tilt. In addition, we also investigated how variability in pelvic landmarks may influence measures of innominate rotational asymmetry and measures of pelvic height. Thirty cadaver pelves were used for the study. Each specimen was positioned in a fixed anatomical reference position and the angle between the ASIS and PSIS measured bilaterally. In addition, side-to-side differences in the height of the innominate bone were recorded. The study found a range of values for the ASIS-PSIS of 0–23 degrees, with a mean of 13 and standard deviation of 5 degrees. Asymmetry of pelvic landmarks resulted in side-to-side differences of up to 11 degrees in ASISPSIS tilt and 16 millimeters in innominate height. These results suggest that variations in pelvic morphology may significantly influence measures of pelvic tilt and innominate rotational asymmetry

Reproducibility of kinematic measures of the thoracic spine, lumbar spine and pelvis during fast running

This study evaluated the reproducibility of the angular rotations of the thoracic spine, lumbar, spine, pelvis and lower extremity during running. In addition, the study compared kinematic, reproducibility between two methods for calculating kinematic trajectories: a six degrees of freedom, (6DOF) approach and a global optimisation (GO) approach. With the first approach segments were, treated independently, however with GO approach joint constraints were imposed to stop translation, of adjacent segments. A total of 12 athletes were tested on two separate days whilst running over, ground at a speed of 5.6ms-1. The results demonstrated good between-day reproducibility for most, kinematic parameters in the frontal and transverse planes with typical angular errors of 1.4-3°., Acceptable repeatability was also found in the sagittal plane. However, in this plane, although, kinematic waveform shape was preserved between testing session, there were sometimes shifts in, curve offset which lead to slightly higher angular errors, typically ranging from 1.9-3.5°. In general, the, results demonstrated similar levels of reproducibility for both computational approaches (6DOF and, GO) and therefore suggest that GO may not lead to improved kinematic reproducibility during running

A 10% increase in step rate improves running kinematics and clinical outcomes in runners with patellofemoral pain at 4 weeks and 3 months

Background: Aberrant frontal plane hip and pelvis kinematics have been frequently observed in runners with patellofemoral pain (PFP). Gait retaining interventions have been shown to improve running kinematics and may therefore be beneficial in runners with PFP. Purpose: the aim of this study was to investigate whether a 10% increase in running step rate influences frontal plane kinematics of the hip and pelvis, as well as clinical outcomes in runners with PFP. Study Design: Case Series Methods: Runners with PFP underwent a 3D gait analysis to confirm the presence of aberrant frontal plane hip and pelvis kinematics at baseline. Twelve participants with frontal plane hip and pelvis kinematics one standard deviation above a reference database, were invited to participate in the gait retraining intervention. Running kinematics along with clinical outcomes of pain and functional measures were recorded at baseline, 4 weeks following retraining and 3-months. Gait retraining consisted of a single session where step rate was increased by 10% using an audible metronome. Participants were asked to continue their normal running while self-monitoring their step rate using a global positioning system watch and audible metronome. Results: Following gait retraining significant improvements in running kinematics and clinical outcomes were observed at 4 week and 3-month follow up. Repeated measures ANOVA with post hoc Bonferroni (p <0.016) showed significant reductions in peak contralateral pelvic drop (Mean Difference [MD], 3.12⁰; 95% Confidence Interval [CI], 1.88⁰, 4.37⁰), hip adduction (MD, 3.99⁰; 95% CI, 2.01⁰, 5.96⁰) and knee flexion (MD, 4.09⁰; 95% CI, 0.04⁰, 8.15⁰), as well as significant increases in self-reported weekly running volume (MD, -13.78km; 95% CI, -22.93km, -4.62km) and longest run pain free (MD, -6.84km; 95% CI, -10.62km, -3.05km). Friedman test with post hoc Wilcoxon signed-rank showed significant improvements in Numerical Rating Scale for worst pain in the past week and Lower Extremity Functional Scale. Conclusion: A single session of gait retraining using a 10% increase in step rate results in significant improvements in running kinematics, pain and function in runners with PFP. These improvements were maintained at 3-month follow up. It is important to assess for aberrant running kinematics at baseline to ensure gait interventions are targeted appropriately. Clinical Relevance: Step rate modification is a simple method of gait retraining that can be easily integrated into clinical practice and running outside of a laboratory setting

Is there a pathological gait associated with common soft tissue running injuries?

Background: Previous research has demonstrated clear associations between specific running injuries and patterns of lower limb kinematics. However, there has been minimal research investigating whether the same kinematic patterns could underlie multiple different soft tissue running injuries. If they do, such kinematic patterns could be considered global contributors to running injury. Hypothesis: Injured runners will demonstrate differences in running kinematics when compared to injury free controls. These kinematic patterns will be consistent amongst injury subgroups. Study Design: Case- Control Study Methods: We studied 72 injured runners and 36 healthy controls. The injured group contained four subgroups of runners with either patellofemoral pain, iliotibial band syndrome, medial tibial stress syndrome or Achilles tendinopathy (n = 18 each). Three-dimensional running kinematics were compared between injured and healthy runners and then between the four injured subgroups. A logistic regression model was used to determine which parameters could be used to identify injured runners. Results: The injured runners demonstrated greater contralateral pelvic drop and forward trunk lean at mid-stance and a more extended knee and dorsiflexed ankle at initial contact. The subgroup ANOVA found these kinematic patterns were consistent across each of the four injury subgroups. Contralateral pelvic drop was found to be the most important variable predicting classification of participants as healthy/injured. Importantly, for every 1° increase in pelvic drop there was an 80% increase in the odds of being classified injured. Conclusion: This study identified a number of global kinematic contributors to common running injuries. In particular, we found injured runners to run with greater peak contralateral pelvic drop and trunk forward lean, as well as an extended knee and dorsiflexed ankle at initial contact. Contralateral pelvic drop appears to be the variable most strongly associated with common running related injuries. Clinical Relevance: The identified kinematic patterns may prove beneficial for clinicians when assessing for biomechanical contributors to running injuries

The between-day repeatability, standard error of measurement and minimal detectable change for discrete kinematic parameters during treadmill running

Background: Kinematic parameters of the trunk, pelvis and lower limbs are frequently associated with both running injuries and performance, and the target of clinical interventions. Currently there is limited evidence reporting the between-day repeatability of discrete kinematic parameters of the trunk, pelvis and lower limbs during treadmill running. Research question: What is the between-day repeatability, standard error of measurement and minimal detectable change of discrete kinematic parameters of the trunk, pelvis and lower limbs during treadmill running? Methods: 16 healthy participants attended two kinematic data collection sessions two weeks apart. Three-dimensional kinematic data were collected while participants ran on a motorised treadmill at 3.2m/s. The interclass correlation coefficient, standard error of measurement and minimal detectable change were calculated for discrete kinematic parameters at initial contact, toe off, peak angles and joint excursions during the stance phase of running. Results: Good to excellent repeatability with low standard error of measurement and minimal detectable change values were observed for sagittal and frontal plane kinematics at initial contact (Range: ICC, 0.829 - 0.941; SEM, 0.6⁰- 2.6⁰; MDC, 1.5⁰- 7.2) and peak angles during stance (Range: ICC, 0.799 – 0.946; SEM, 0.6⁰- 2.6⁰; MDC, 1.7⁰- 7.1⁰). Peak transverse plane kinematics of the hip (ICC, 0.783; SEM, 3.2⁰; MDC, 8.7⁰) and knee (ICC, 0.739; SEM, 3⁰; MDC, 8.4⁰) demonstrated moderate between-day repeatability with large SEM and MDC values. Kinematics at toe off demonstrated the lowest ICC values and largest measurement errors of all parameters (Range: ICC, 0.109 – 0.900; SEM, 0.8⁰- 5.7⁰; MDC, 2.5⁰- 15.7⁰). Significance: This is the first study detailing the measurement error and minimal detectable change for discrete kinematic parameters of the trunk and pelvis during treadmill running. The reported values may provide a useful reference point for future studies investigating between-day differences in running kinematics

Kinematic characteristics of male runners with a history of recurrent calf muscle strain injury

Background: Calf muscle strain injuries are a common running injury affecting male runners and are known to have high reoccurrence rates. Currently, limited evidence exists investigating factors associated with this injury with no previous study investigating the running kinematics of male runners with a history of repeat calf muscle strain injuries. Purpose: To investigate differences in running kinematics between runners with a history of recurrent calf muscle strain injury and injury free controls. Study Design: Case-control investigation Level of Evidence: 4 Methods: Stance phase kinematics were compared between 15 male runners with a history of calf muscle strain injury and 15 male control participants during treadmill running at 3.2m/s. Independent t-tests were used to compare differences in stance phase kinematic parameters between groups and effect sizes were calculated using Cohen’s d. Results: The group with a history of calf muscle strain injury demonstrated a significant 2.1⁰ and 3.1⁰ increase in contralateral pelvic drop and anterior pelvic tilt during mid stance. In addition, this group exhibited longer stance times and a more anterior tilted pelvis, flexed hip and a greater distance between the heel and centre of mass at initial contact. Large effect sizes, greater than 0.8, were observed for all differences. No significant differences were observed for ankle and knee joint kinematics between the groups. Conclusion: This is the first study to identify kinematic characteristics associated with recurrent calf muscle strain injury. While it is not possible to determine causality, the observed kinematic differences may contribute to recurrent nature of this injury. Specifically, it is possible that neuromuscular deficits of the hip and calf muscle complex may lead to increased strain on the calf complex. Rehabilitation interventions which focus on addressing pelvis and hip kinematics may reduce the demands placed upon the calf complex and could prove clinically effective

Oldest known pantherine skull and evolution of the tiger

The tiger is one of the most iconic extant animals, and its origin and evolution have been intensely debated. Fossils attributable to extant pantherine species-lineages are less than 2 MYA and the earliest tiger fossils are from the Calabrian, Lower Pleistocene. Molecular studies predict a much younger age for the divergence of modern tiger subspecies at <100 KYA, although their cranial morphology is readily distinguishable, indicating that early Pleistocene tigers would likely have differed markedly anatomically from extant tigers. Such inferences are hampered by the fact that well-known fossil tiger material is middle to late Pleistocene in age. Here we describe a new species of pantherine cat from Longdan, Gansu Province, China, Panthera zdanskyi sp. nov. With an estimated age of 2.55–2.16 MYA it represents the oldest complete skull of a pantherine cat hitherto found. Although smaller, it appears morphologically to be surprisingly similar to modern tigers considering its age. Morphological, morphometric, and cladistic analyses are congruent in confirming its very close affinity to the tiger, and it may be regarded as the most primitive species of the tiger lineage, demonstrating the first unequivocal presence of a modern pantherine species-lineage in the basal stage of the Pleistocene (Gelasian; traditionally considered to be Late Pliocene). This find supports a north-central Chinese origin of the tiger lineage, and demonstrates that various parts of the cranium, mandible, and dentition evolved at different rates. An increase in size and a reduction in the relative size of parts of the dentition appear to have been prominent features of tiger evolution, whereas the distinctive cranial morphology of modern tigers was established very early in their evolutionary history. The evolutionary trend of increasing size in the tiger lineage is likely coupled to the evolution of its primary prey species

Does a SLAP lesion affect shoulder muscle recruitment as measured by EMG activity during a rugby tackle?

Background: The study objective was to assess the influence of a SLAP lesion on onset of EMG activity in shoulder muscles during a front on rugby football tackle within professional rugby players. Methods: Mixed cross-sectional study evaluating between and within group differences in EMG onset times. Testing was carried out within the physiotherapy department of a university sports medicine clinic. The test group consisted of 7 players with clinically diagnosed SLAP lesions, later verified on arthroscopy. The reference group consisted of 15 uninjured and full time professional rugby players from within the same playing squad. Controlled tackles were performed against a tackle dummy. Onset of EMG activity was assessed from surface EMG of Pectorialis Major, Biceps Brachii, Latissimus Dorsi, Serratus Anterior and Infraspinatus muscles relative to time of impact. Analysis of differences in activation timing between muscles and limbs (injured versus non-injured side and non injured side versus matched reference group). Results: Serratus Anterior was activated prior to all other muscles in all (P = 0.001-0.03) subjects. In the SLAP injured shoulder Biceps was activated later than in the non-injured side. Onset times of all muscles of the noninjured shoulder in the injured player were consistently earlier compared with the reference group. Whereas, within the injured shoulder, all muscle activation timings were later than in the reference group. Conclusions: This study shows that in shoulders with a SLAP lesion there is a trend towards delay in activation time of Biceps and other muscles with the exception of an associated earlier onset of activation of Serratus anterior, possibly due to a coping strategy to protect glenohumeral stability and thoraco-scapular stability. This trend was not statistically significant in all cases

Impaired perception of facial motion in autism spectrum disorder

Copyright: © 2014 O’Brien et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.This article has been made available through the Brunel Open Access Publishing Fund.Facial motion is a special type of biological motion that transmits cues for socio-emotional communication and enables the discrimination of properties such as gender and identity. We used animated average faces to examine the ability of adults with autism spectrum disorders (ASD) to perceive facial motion. Participants completed increasingly difficult tasks involving the discrimination of (1) sequences of facial motion, (2) the identity of individuals based on their facial motion and (3) the gender of individuals. Stimuli were presented in both upright and upside-down orientations to test for the difference in inversion effects often found when comparing ASD with controls in face perception. The ASD group’s performance was impaired relative to the control group in all three tasks and unlike the control group, the individuals with ASD failed to show an inversion effect. These results point to a deficit in facial biological motion processing in people with autism, which we suggest is linked to deficits in lower level motion processing we have previously reported

17β-Estradiol Prevents Early-Stage Atherosclerosis in Estrogen Receptor-Alpha Deficient Female Mice

Estrogen is atheroprotective and a high-affinity ligand for both known estrogen receptors, ERα and ERβ. However, the role of the ERα in early-stage atherosclerosis has not been directly investigated and is incompletely understood. ERα-deficient (ERα−/−) and wild-type (ERα+/+) female mice consuming an atherogenic diet were studied concurrent with estrogen replacement to distinguish the actions of 17β-estradiol (E2) from those of ERα on the development of early atherosclerotic lesions. Mice were ovariectomized and implanted with subcutaneous slow-release pellets designed to deliver 6 or 8 μg/day of exogenous 17β-estradiol (E2) for a period of up to 4 months. Ovariectomized mice (OVX) with placebo pellets (E2-deficient controls) were compared to mice with endogenous E2 (intact ovaries) and exogenous E2. Aortas were analyzed for lesion area, number, and distribution. Lipid and hormone levels were also determined. Compared to OVX, early lesion development was significantly (p < 0.001) attenuated by E2 with 55–64% reduction in lesion area by endogenous E2 and >90% reduction by exogenous E2. Compared to OVX, a decline in lesion number (2- to 4-fold) and lesser predilection (~4-fold) of lesion formation in the proximal aorta also occurred with E2. Lesion size, development, number, and distribution inversely correlated with circulating plasma E2 levels. However, atheroprotection was independent of ERα status, and E2 athero-protection in both genotypes was not explained by changes in plasma lipid levels (total cholesterol, triglyceride, and high-density lipoprotein cholesterol). The ERα is not essential for endogenous/exogenous E2-mediated protection against early-stage atherosclerosis. These observations have potentially significant implications for understanding the molecular and cellular mechanisms and timing of estrogen action in different estrogen receptor (ER) deletion murine models of atherosclerosis, as well as implications to human studies of ER polymorphisms and lipid metabolism. Our findings may contribute to future improved clinical decision-making concerning the use of hormone therapy